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CAR T-cell manufacturing conditions are critical to differentiation, metabolic fitness, and cytotoxic function, enhancing therapy efficacy and production efficiency.
Demonstration of the wide range of metabolic rates that can be quantified on the Agilent Seahorse XF Flex analyzer through the use of different Seahorse XF microplates and in vitro differentiation of adipocytes.
Poster for the annual meeting (2025) of American Association of Immunologists, showing exhausted T cells generated through chronic beads activation have a distinct and consistent metabolic phenotype that can be assess using XF Pro and T Cell...
This flyer describes the new Seahorse XF Flex 3D Capture Microplate, and the improvements it includes over other plates in the Seahorse cell culture plate portfolio.It also includes data generated with the plate, and ordering information.
Overview of the benefits of the Agilent Seahorse XF tissue metabolism workflow using the Seahorse XF Flex Analyzer and the Seahorse XF Flex 3D Capture Microplates-L
An optimized Agilent XF 3D tissue workflow that allows for detection and quantitative assessment of energy metabolism in tissue materials is presented.
Find Agilent Seahorse XF Flex analyzer general instrument and performance specifications
AACR 2025 poster: Chronic anti-CD3/CD28 stimulation during cell expansion generates exhausted T cells with a distinct metabolic and cytotoxic phenotype
2025 flyer for the Agilent Seahorse XF 3D Mito Stress Test Kit for a comprehensive profile of mitochondrial function in 3D models.
The poster introduces a multiparametric workflow that allows for evaluating contractility, viability, and metabolic function using validated human iPSC-derived cardiomyocytes to better understand the mechanisms associated with drug-induced...
we demonstrated consistent production of CAR T-cells using the functionally closed and automated cell manufacturing Lonza Cocoon platform, using a novelcombination of cell analysis parameters obtained from an Agilent xCELLigence RTCA system, a...
Operating manual for the Agilent Seahorse XF Flex instrument.
This editorial showcases Agilent solutions for metabolic modulation enhancing CAR T-cell activation, persistence, and serial killing for improved cancer immunotherapy
CAR-TCR 2024 Poster. We demonstrated the successful production of CAR T-cells using the Lonza Cocoon system. Additionally, CAR T-cell in-process analyses and critical process parameters were evaluated using the combination of a flow cytometer, a...
Research highlight confirming the critical role of metabolic fitness in CAR-NK cells and its importance to achieve superior clinical outcomes in immunotherapy.