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本應(yīng)用摘要提供了一套完整的高通量工作流程解決方案，可應(yīng)對各種 mAb 產(chǎn)品的分析。
本文以半胱氨酸連接的抗體藥物偶聯(lián)物 (ADC) 為研究對象，使用天然質(zhì)譜法，通過 Agilent 6530 Q-TOF LC/MS 檢測 ADC 的完整分子量，并使用安捷倫 DAR 計算器軟件計算 ADC 的加權(quán)平均藥物/抗體比率(DAR)。
本文以半胱氨酸連接的抗體藥物偶聯(lián)物為研究對象，使用連接 PLRP-S 反相液相色譜柱的 Agilent 1290 Infinity II 液相色譜系統(tǒng)分離還原的輕鏈、重鏈和相對應(yīng)連接藥物的輕重鏈，并通過 Agilent 6530 高分辨率四極桿飛行時間 (Q-TOF) 液質(zhì)聯(lián)用系統(tǒng)對各個色譜峰進(jìn)行鑒...
This application note describes a robust LC/MS method for the analysis of native mAb-siRNA conjugates.
Presents the use of AdvanceBio Desalting-RP cartridges to pretreat mAb and ADC samples before MS analysis.
Presents the use of the Agilent Bio SEC-3 column to aid HRMS characterization of mAbs and ADCs.
Easy-to-use and fully integrated method for determination of DAR values for ADCs
| 韓語 (朝鮮) | 完整版（PDF） |
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Using Automated Affinity Purification, LC/MS analysis, and Novel DAR Calculation Software
| 韓語 (朝鮮) | 完整版（PDF） |
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Using Multiple Heart-cutting Hydrophobic Interaction/Reversed Phase 2D-LC/MS
Analysis of an mAb (trastuzumab) and an ADC (trastuzumab emtansine) by size exclusion chromatography with online mass spectrometry (SEC-MS)
Methods using Agilent AdvanceBio SEC columns are developed for the characterization of components of standard protein mixtures.
Methods using Agilent AdvanceBio SEC columns are developed for the characterization of components of standard protein mixtures.