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This application note presents different approaches to native mass spectrometry.
During the drug discovery process, permeability assays such as Caco-2 (cell line) and PAMPA (parallel artificial membrane permeation assay) are utilized to mimic the absorption of potential drug candidates by the cells of the human intestine.
Do you want to open new avenues for pursuing small molecule and protein drug targets—without using surrogates, radioactivity, coupled assays, or indirect measurements? The Agilent RapidFire 400 high-throughput mass spectrometry system delivers...
This application note describes a method for automated MHC-I associated peptide enrichment using the Agilent AssayMAP Bravo platform with large-capacity (25 μL) cartridges for immunopeptidomics analysis.
This application note showcases the quantitative performance of multiple reaction monitoring (MRM)-based LC/MS analysis of peptides derived from protein biomarkers in human plasma using the Agilent 1290 Infinity II LC system coupled to the Agilent...
This application note describes a robust LC/MS method for the analysis of native mAb-siRNA conjugates.
This application note describes a robust LC/MS method for the analysis of native protein analysis.
Describes a workflow for monitoring multiple mAb characteristics involving the Agilent 1290 Infinity II 2D-LC System.
This application note presents the use of the Agilent 6560 ion mobility LC/Q-TOF to analyze the formation of multimers of bovine serum albumin (BSA) in various mobile phases.
Critical Quality Attribute Monitoring of mAbs at the Intact and Subunit Levels
An automated workflow for the analysis of protein phosphorylation from sample preparation with phosphopeptide enrichment to analysis by IMS.
This application note describes a method for quantitative analysis of intact monoclonal antibodies (mAbs) in a serum matrix.
Presents a method for protein analysis using an Agilent LC/MSD XT and 1260 Infinity II LC.
Identification of NISTmAb Charge Variants by Fully Automated Capillary Isoelectric Focusing and Mass Spectrometry
Presents a method for peptide mapping using an Agilent LC/MSD XT and 1290 Infinity II LC.
Presents the use of AdvanceBio Desalting-RP cartridges to pretreat mAb and ADC samples before MS analysis.
Presents the use of the Agilent Bio SEC-3 column to aid HRMS characterization of mAbs and ADCs.
An Agilent LC system, ZORBAX column and optimized LC gradient were used for fast separation of blood plasma lipids with 15 minutes cycle time injection-to injection.
This application note evaluates the performance of an Agilent LC/MS in terms of achievable mass accuracy and spectral accuracy to enable unknown formula ID.