Agilent’s Chemically Synthesized Guide RNAs are the industry standard for quality nucleic acids. Using a patented, proprietary chemistry makes the synthesis of long RNA oligonucleotides extremely robust and efficient. This chemistry is used to synthesize and deliver high quality CRISPR guides, and our processing provides guides with fewer contaminants, for quick and easy editing with the highest indel frequency and reproducibility. Agilent has also developed chemical modifications which improve the efficiency, stability and specificity of guide RNAs in a variety of cell types.

Agilent’s cGMP facilities produce clinical-grade sgRNA material for human therapeutic use, developing analytical methods and processes that optimize purity and yield.