The Oligo Pro II system utilizes UV detection along with parallel capillary electrophoresis to provide single nucleotide resolution and direct assessment of oligonucleotide purity, eliminating the need for intercalating dyes and fluorescent probes. The Oligo Pro II can quickly adjust to demands with either a 12-capillary, 24-capillary or 96-capillary array, while the software automates capillary conditioning, sample injection, electrophoresis separation and data processing.